Sodium Methoxide → HCID 86747118, compound

Participants

Reaction Conditions

Reaction Steps

4.7 g (0.026 mol) of 30% strength sodium methylate were added over the course of 10 minutes to 6.0 g (0.0263 mol) of 4-chlorodifluoromethoxy-6-fluoro-2-methylaminopyrimidine in 100 ml of methanol while stirring at 0° C. The mixture was stirred at 0° C. and at 25° C. for 1 hour each and worked up as usual, resulting in 6.3 g (100% of theory) of the title compound of melting point 49-53° C.

Provenance & Evidence