HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → Phenylhydantoin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Catalyst | Triphenylphosphine | HCID 11776 | — |
| Catalyst | Lithium Bromide | HCID 82050 | — |
| Catalyst | Palladium bromide (PdBr2) | HCID 83469 | — |
| Product | Phenylhydantoin | HCID 1002 | 50% |
Reaction Steps
2,600 g benzaldehyde, 1,500 g urea, 25 ml N-methylpyrrolidone, 0.017 g palladium(II) bromide, 0.033 g triphenylphosphane, 0.100 9 sulfuric acid and 0.760 g lithium bromide are reacted in a 300 ml autoclave under 60 bar at 80° C. After a reaction time of 12 hours, the solvent is removed in vacuo and the residue is analyzed by means of high pressure liquid chromatography (HPLC). 2,200 g 5-phenylhydantoin are formed. This corresponds to a yield of 50%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235910B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-e82aa72cdcbc495e967cc07059ae3f75 |
| Source note | uspto-grants-2001_05 |