Ethylamine → HCID 9951648, compound

HRID 1978282Notes

Reaction equation

HRID 1978282 reaction equation
[NH:1]([C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])[C@H:2]([C:7]([NH:9][C@H:10]([C:13](C(OCC)=O)=[O:14])[CH2:11][CH3:12])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[CH2:30]([NH2:32])[CH3:31]>C(Cl)(Cl)Cl.CO>[NH:1]([C:20]([O:22][CH2:23][C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:21])[C@H:2]([C:7]([NH:9][C@H:10]([C:13]([NH:32][CH2:30][CH3:31])=[O:14])[CH2:11][CH3:12])=[O:8])[CH2:3][CH:4]([CH3:5])[CH3:6]

Participants

4

Reactant 2

HCID 6341EthylamineHCID 131719100HCID 131719100, compound

Product 1

HCID 9951648HCID 9951648, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

This compound was synthesized from protected α-ketoester derived from Z—Leu—Abu—CO2Et and ethylamine in 64% yield by the procedure described in Example 1. Single spot on TlC, Rf=0.36 (CHCl3/CH3OH 50;1); mp 130-132° C. Anal. calcd. for C21H31N3O5:405.45; C, 62.20; H, 7.71; N, 10.36. Found: C, 61.92; H, 7.62; N, 10.31. NMR (CDCl3) ok. MS (FAB) m/e=406 (M+1).

Sources & evidence

ORD record
ord-c66d5a6de9be4469ac83e4b9749c1c60
Source dataset
uspto-grants-2001_05
Patent number
US06235929B1

Reaction notes

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