反应详情

A solution of 5.775 g (19.900 mM) of tert-butyl 4-(2-bromoethylidene)piperidine-1-carboxylate and 4.05 g (21.9 mM) of potassium phthalimide in 100 ml of N,N-dimethylformamide was stirred at 100° C. for 1 hour. This reaction mixture was poured in water and extracted with 3 portions of ethyl acetate. The pooled organic layer was dried over anhydrous magnesium sulfate (MgSO4) and the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate=6/1 to 3/1) to provide the title compound.

1. extractionextracted with 3 portions of ethyl acetate
2. dry with materialThe pooled organic layer was dried over anhydrous magnesium sulfate (MgSO4)
3. distillationthe solvent was distilled off under reduced pressure
4. customThe residue was purified by silica gel column chromatography (hexane/ethyl acetate=6/1 to 3/1)