4-Aminocyclohexanecarboxylic acid → Methyl 4-aminocyclohexane-1-carboxylate--hydrogen chloride (1/1)

HRID 1978334Notes

Reaction equation

HRID 1978334 reaction equation
[NH2:1][CH:2]1[CH2:7][CH2:6][CH:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.[ClH:11].[CH3:12]O>>[ClH:11].[NH2:1][CH:2]1[CH2:7][CH2:6][CH:5]([C:8]([O:10][CH3:12])=[O:9])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 1715604-Aminocyclohexanecarboxylic acidHCID 21893726Hydrochloride methanol

Product 1

HCID 18521575Methyl 4-aminocyclohexane-1-carboxylate--hydrogen chloride (1/1)

Procedure

To 5.109 g (35.680 mM) of 4-aminocyclohexane-carboxylic acid was added 50 ml of 10% HCl/methanol and the mixture was refluxed overnight. The solvent was then distilled off under reduced pressure and the residue was crystallized from methanol-diethyl ether to provide the title compound.

Workup

  1. temperaturethe mixture was refluxed overnight
  2. distillationThe solvent was then distilled off under reduced pressure
  3. customthe residue was crystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-aeb2297a17b2433a91c3e467c9acd3bb
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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