反应详情

A solution of imidazo[1,2-a]pyridine-5-thiol (448 mg), ethyl thioglycolate (0.36 ml), and sodium ethoxide (210 mg) in ethanol (10 ml) was refluxed with stirring for 3 hours. The mixture was then allowed to cool and concentrated. The residue was diluted with ethyl acetate (10 ml) and extracted with 1N-hydrochloric acid. The aqueous layer was neutralized with 1N-NaOH/water and extracted with ethyl acetate, and the organic layer was washed with water and concentrated. The resulting crystals were collected, rinsed with diisopropyl ether (20 ml), and dried to provide the title compound (430 mg, 65%).

1. temperatureto cool
2. concentrationconcentrated
3. additionThe residue was diluted with ethyl acetate (10 ml)
4. extractionextracted with 1N-hydrochloric acid
5. extractionextracted with ethyl acetate
6. washthe organic layer was washed with water
7. concentrationconcentrated
8. customThe resulting crystals were collected
9. washrinsed with diisopropyl ether (20 ml)
10. customdried