Hydrochloric Acid → HCID 21993962, compound

HRID 1978362Notes

Reaction equation

HRID 1978362 reaction equation
C(OC([NH:8][CH2:9][C:10]1[CH:28]=[CH:27][C:13]([CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)=[CH:12][CH:11]=1)=O)(C)(C)C.[ClH:29]>C(O)C>[ClH:29].[ClH:29].[NH2:8][CH2:9][C:10]1[CH:11]=[CH:12][C:13]([CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=3)[CH2:17][CH2:16]2)=[CH:27][CH:28]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21994022HCID 21994022, compound

Product 1

HCID 21993962HCID 21993962, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5.77 g (15.16 mM) of 1-[4-[N-(tert-butoxycarbonyl)aminomethyl]benzyl]-4-phenylpiperidine was added 10 ml (120 mM) of 12N-hydrochloric acid at room temperature and the mixture was stirred at the prevailing temperature for 2 hours. To this reaction mixture was added ethanol and the mixture was concentrated under reduced pressure. To the residue were added ethanol and diethyl ether and the resulting crystals were harvested by filtration. This crystal crop was rinsed with ethanol and diethyl ether to provide the title compound as white crystals.

Workup

  1. concentrationthe mixture was concentrated under reduced pressure
  2. additionTo the residue were added ethanol and diethyl ether
  3. filtrationthe resulting crystals were harvested by filtration
  4. washThis crystal crop was rinsed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-5ac282f4b23d402480bfae1bb96d37d6
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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