1-Boc-4-(aminomethyl)piperidine → HCID 21993912, compound

HRID 1978370Notes

Reaction equation

HRID 1978370 reaction equation
[O:1]([P:8]([CH2:17][S:18](OC1C=CC=CC=1)(=[O:20])=[O:19])([O:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)=[O:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:28]([O:32][C:33]([N:35]1[CH2:40][CH2:39][CH:38]([CH2:41][NH2:42])[CH2:37][CH2:36]1)=[O:34])([CH3:31])([CH3:30])[CH3:29]>C1(C)C=CC=CC=1>[O:10]([P:8]([CH2:17][S:18]([NH:42][CH2:41][CH:38]1[CH2:39][CH2:40][N:35]([C:33]([O:32][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:34])[CH2:36][CH2:37]1)(=[O:20])=[O:19])([O:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)=[O:9])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 7368171-Boc-4-(aminomethyl)piperidineHCID 12549382HCID 12549382, compound

Product 1

HCID 21993912HCID 21993912, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of 2.405 g (5.947 mM) of phenyl di-phenoxyphosphorylmethanesulfonate and 1.66 g (7.73 mM) of 1-(tert-butoxycarbonyl)piperidine-4-ylmethylamine in 50 ml of toluene was refluxed overnight. The solvent was then distilled off under reduced pressure and the residue was purified by silica gel column chromatography (hexane-ethyl acetate:2/1 to 1/1) to provide the title compound.

Workup

  1. distillationThe solvent was then distilled off under reduced pressure
  2. customthe residue was purified by silica gel column chromatography (hexane-ethyl acetate:2/1 to 1/1)

Sources & evidence

ORD record
ord-15d5e5acccdf4c16a3dff16c1b7a01cd
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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