反应详情

温度

0 °C

To a solution of 3.00 g (12.18 mM) of ethyl 5-thia-1,8b-diazaacenaphthylene-4-carboxylate in methanol (9 ml) was added 18 ml (18 mM) of 1N-aqueous solution of sodium hydroxide at room temperature and the mixture was stirred for 2.5 hours. This reaction mixture was cooled to 0° C. and 1N-hydrochloric acid was added until the pH had been brought to 5. The resulting crystals were harvested by filtration. This crystal crop was rinsed with water, ethanol and diethyl ether to provide the title compound as orange-colored solid (yield 1.98 g, 69%).

1. filtrationThe resulting crystals were harvested by filtration
2. washThis crystal crop was rinsed with water, ethanol and diethyl ether