Hydrochloric Acid → HCID 10943925, compound

HRID 1978371Notes

Reaction equation

HRID 1978371 reaction equation
[N:1]1[CH:2]=[C:3]2[N:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]=13)[S:6][C:5]([C:13]([O:15]CC)=[O:14])=[CH:4]2.[OH-].[Na+].Cl>CO>[N:1]1[CH:2]=[C:3]2[N:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]=13)[S:6][C:5]([C:13]([OH:15])=[O:14])=[CH:4]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12038723HCID 12038723, compound

Product 1

HCID 10943925HCID 10943925, compoundYield 74.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

To a solution of 3.00 g (12.18 mM) of ethyl 5-thia-1,8b-diazaacenaphthylene-4-carboxylate in methanol (9 ml) was added 18 ml (18 mM) of 1N-aqueous solution of sodium hydroxide at room temperature and the mixture was stirred for 2.5 hours. This reaction mixture was cooled to 0° C. and 1N-hydrochloric acid was added until the pH had been brought to 5. The resulting crystals were harvested by filtration. This crystal crop was rinsed with water, ethanol and diethyl ether to provide the title compound as orange-colored solid (yield 1.98 g, 69%).

Workup

  1. filtrationThe resulting crystals were harvested by filtration
  2. washThis crystal crop was rinsed with water, ethanol and diethyl ether

Sources & evidence

ORD record
ord-d24f409ea2bf4afaa7e096acc9f224cf
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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