Hydrochloric Acid → 1H-1,4-Diazepine, hexahydro-1-(3-phenylpropyl)-, hydrochloride (1:2)

HRID 1978374Notes

Reaction equation

HRID 1978374 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:16][CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:24]>C(O)C>[ClH:24].[ClH:24].[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:16][CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21994061HCID 21994061, compound

Product 1

HCID 219936901H-1,4-Diazepine, hexahydro-1-(3-phenylpropyl)-, hydrochloride (1:2)

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 5.41 g (5.41 g (16.99 mmol.) of tert-butyl 4-(3-phenylpropan-1-yl)-2,3,5,6-tetrahydro-7H-1,4-diazepine-1-carboxylate was added, at room temperature, 5 ml (60 mmol.) of 12N hydrochloric acid. The mixture was stirred for 2 hours. To the reaction system was added ethanol, then the solvent was distilled off under reduced pressure to give the object compound as a pale yellow amorphous product. The yield was 5.65 g (100%).

Workup

  1. distillationthe solvent was distilled off under reduced pressure
  2. customto give the object compound as a pale yellow amorphous product

Sources & evidence

ORD record
ord-93d64ea0f2804ca5aff7510c7e20c2b8
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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