反应详情

To 9.76 g (32.06 mmol.) of trans-1-tert-butoxycarbonyl-2,5-dimethyl-4-benzyl piperazine was added, at room temperature, 10 ml (120 mmol.) of 12N hydrochloric acid. The mixture was stirred for one hour. The solvent was distilled off under reduced pressure. To the residue was added 2-propanol, which was further concentrated. To the concentrate was added diethyl ether. The resulting crystals were collected by filtration and washed with 2-propanol and diethyl ether to give the object compound as white crystals. The yield was 7.97 g (90%).

1. distillationThe solvent was distilled off under reduced pressure
2. additionTo the residue was added 2-propanol, which
3. concentrationwas further concentrated
4. additionTo the concentrate was added diethyl ether
5. filtrationThe resulting crystals were collected by filtration
6. washwashed with 2-propanol and diethyl ether