HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-Fluoroimidazo[1,2-a]pyridine--hydrogen chloride (1/1)
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 5-Fluoroimidazo[1,2-a]pyridine | HCID 10975536 | — |
| Product | 5-Fluoroimidazo[1,2-a]pyridine--hydrogen chloride (1/1) | HCID 21993641 | — |
Reaction Steps
To the black liquid 5-fluoroimidazo[1,2-a]pyridine (650 mg) was added conc. hydrochloric acid (5 mL). The mixture was concentrated, which was crystallized from a mixture of ethanol, THF and ethyl acetate (10 mL:50 mL:200 mL) to afford 5-fluoroimidazo[1,2-a]pyridine monohydrochloride as a powdery product (690 mg, yield 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235731B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-04700b992a2c429c811b4c3070ef2360 |
| Source note | uspto-grants-2001_05 |