Hydrochloric Acid → 5-Fluoroimidazo[1,2-a]pyridine--hydrogen chloride (1/1)

HRID 1978387Notes

Reaction equation

HRID 1978387 reaction equation
[F:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1.[ClH:11]>>[ClH:11].[F:1][C:2]1[N:7]2[CH:8]=[CH:9][N:10]=[C:6]2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 109755365-Fluoroimidazo[1,2-a]pyridine

Product 1

HCID 219936415-Fluoroimidazo[1,2-a]pyridine--hydrogen chloride (1/1)

Procedure

To the black liquid 5-fluoroimidazo[1,2-a]pyridine (650 mg) was added conc. hydrochloric acid (5 mL). The mixture was concentrated, which was crystallized from a mixture of ethanol, THF and ethyl acetate (10 mL:50 mL:200 mL) to afford 5-fluoroimidazo[1,2-a]pyridine monohydrochloride as a powdery product (690 mg, yield 83%).

Workup

  1. concentrationThe mixture was concentrated
  2. customwhich was crystallized from a mixture of ethanol, THF and ethyl acetate (10 mL:50 mL:200 mL)

Sources & evidence

ORD record
ord-04700b992a2c429c811b4c3070ef2360
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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