Hydrochloric Acid → HCID 10943925, compound

HRID 1978388Notes

Reaction equation

HRID 1978388 reaction equation
[N:1]1[CH:2]=[C:3]2[N:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]=13)[S:6][C:5]([C:13]([O:15]CC)=[O:14])=[CH:4]2.[OH-].[Na+].Cl>C(O)C.O>[N:1]1[CH:2]=[C:3]2[N:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]=13)[S:6][C:5]([C:13]([OH:15])=[O:14])=[CH:4]2

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12038723HCID 12038723, compound

Product 1

HCID 10943925HCID 10943925, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

To a solution of 193.69 g of ethyl 5-thia-1,8b-diazaacenaphthylene-4-carboxylate in 1 liter of ethanol was added a solution of 62.9 g (1.57 mol.) of sodium hydroxide in 50 mL of water. The mixture was stirred for 0.5 hour at room temperature. To the reaction mixture was added about 130 mL of conc. hydrochloric acid while stirring until the pH became about 4-5. The resulting precipitate was collected by filtration. which was washed with ethanol, acetone and diethyl ether successively to give 5-thia-1,8b-diazaacenaphthylene-4-carboxylic acid.

Workup

  1. stirringwhile stirring until the pH
  2. filtrationThe resulting precipitate was collected by filtration
  3. washwhich was washed with ethanol, acetone and diethyl ether successively

Sources & evidence

ORD record
ord-c4f10ef648c44587857907646c8e5bbe
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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