Hydrochloric Acid → HCID 21993668, compound

HRID 1978403Notes

Reaction equation

HRID 1978403 reaction equation
Cl.C(OC([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[C:11](=[O:24])[CH2:10]1)=O)(C)(C)C.[OH-].[Na+]>>[C:18]1([CH2:17][CH2:16][CH2:15][N:12]2[CH2:13][CH2:14][NH:9][CH2:10][C:11]2=[O:24])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 21994084HCID 21994084, compound

Product 1

HCID 21993668HCID 21993668, compoundYield 94.3%

Procedure

Concentrated hydrochloric acid (4.2 ml) was added to 4-tert-butoxycarbonyl-1-(3-phenylpropan-1-yl)-2-oxopiperazine (3.85 g, 12.1 mmol) at room temperature and the mixture was stirred at room temperature for 1 hour. The reaction mixture was basified with 8N-sodium hydroxide and extracted with ethyl acetate. The extract was washed with brine, dried over MgSO4 and concentrated in vacuo to give 1-(3-phenylpropan-1-yl)-2-oxopiperazine as a colorless oil (2.49 g, 94%).

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over MgSO4
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-3d8f4c82aae449a892eb806c279c53c2
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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