HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → (r)-n-[1-(1,4-Benzodioxan-2-ylmethyl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (R)-N-[1-(1,4-benzodioxan-2-ylmethyl)piperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide | HCID 9804407 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | (r)-n-[1-(1,4-Benzodioxan-2-ylmethyl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride | HCID 70248258 | — |
Reaction Steps
In 1 ml of methanol was dissolved 0.452 g of (R)-N-[1-(1,4-benzodioxan-2-ylmethyl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide, followed by addition of an excess of methanolic HCl. The mixture was stirred and concentrated to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235731B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-9bf268c4b79049e198687da24b6ad34c |
| Source note | uspto-grants-2001_05 |