Hydrochloric Acid → (r)-n-[1-(1,4-Benzodioxan-2-ylmethyl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978409Notes

Reaction equation

HRID 1978409 reaction equation
[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][C@H:2]1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:14][CH2:13]1.[ClH:34]>CO>[ClH:34].[ClH:34].[O:1]1[C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[O:4][CH2:3][C@H:2]1[CH2:11][N:12]1[CH2:17][CH2:16][CH:15]([CH2:18][NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9804407(R)-N-[1-(1,4-benzodioxan-2-ylmethyl)piperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Product 1

HCID 70248258(r)-n-[1-(1,4-Benzodioxan-2-ylmethyl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 1 ml of methanol was dissolved 0.452 g of (R)-N-[1-(1,4-benzodioxan-2-ylmethyl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide, followed by addition of an excess of methanolic HCl. The mixture was stirred and concentrated to provide the title compound.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-9bf268c4b79049e198687da24b6ad34c
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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