Hydrochloric Acid → HCID 70247330, compound

HRID 1978418Notes

Reaction equation

HRID 1978418 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16](=[O:31])[CH:17]=[CH:18][C:19]2[S:29][C:28]3[N:30]4[C:21](=[CH:22][N:23]=[C:24]4[CH:25]=[CH:26][CH:27]=3)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>C(O)C>[ClH:32].[ClH:32].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16](=[O:31])[CH:17]=[CH:18][C:19]2[S:29][C:28]3[N:30]4[C:21](=[CH:22][N:23]=[C:24]4[CH:25]=[CH:26][CH:27]=3)[CH:20]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70248359HCID 70248359, compound

Product 1

HCID 70247330HCID 70247330, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To this crude N-[1-(tert-butoxycarbonyl)piperidin-4-ylmethyl]-3-(5-thia-1,8b-diazaacenaphthylen-4-yl)acrylamide was added 1 ml of concentrated hydrochloric acid and the mixture was stirred at room temperature for 0.5 hour. After addition of ethanol, the mixture was stirred and the resulting precipitate was collected and washed serially with ethanol and diethyl ether to provide the title compound.

Workup

  1. stirringthe mixture was stirred
  2. customthe resulting precipitate was collected
  3. washwashed serially with ethanol and diethyl ether

Sources & evidence

ORD record
ord-373810fc5d264c3893955c649536d98b
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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