Hydrochloric Acid → HCID 70247174, compound

HRID 1978419Notes

Reaction equation

HRID 1978419 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][NH:17][C:18](=[O:33])[CH:19]=[CH:20][C:21]3[S:31][C:30]4[N:32]5[C:23](=[CH:24][N:25]=[C:26]5[CH:27]=[CH:28][CH:29]=4)[CH:22]=3)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:34]>CO>[ClH:34].[ClH:34].[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([CH2:16][NH:17][C:18](=[O:33])[CH:19]=[CH:20][C:21]3[S:31][C:30]4[N:32]5[C:23](=[CH:24][N:25]=[C:26]5[CH:27]=[CH:28][CH:29]=4)[CH:22]=3)[CH2:14][CH2:15]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 54288046HCID 54288046, compound

Product 1

HCID 70247174HCID 70247174, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 2 ml of methanol was dissolved 0.305 g of N-[1-(3-phenylpropan-1-yl)piperidin-4-ylmethyl]-3-(5-thia-1,8b-diazaacenaphthylen-4-yl)acrylamide, followed by addition of a stoichiometric excess of methanolic hydrochloric acid. The mixture was stirred and concentrated and the residue was crystallized from ethanol-diethyl ether to provide the title compound.

Workup

  1. concentrationconcentrated
  2. customthe residue was crystallized from ethanol-diethyl ether

Sources & evidence

ORD record
ord-1b6e010d42aa4627b23052a1db485130
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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