Hydrochloric Acid → HCID 21993603, compound

HRID 1978438Notes

Reaction equation

HRID 1978438 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>C(O)C>[ClH:32].[ClH:32].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][NH:17][C:18]([C:20]2[S:30][C:29]3[N:31]4[C:22](=[CH:23][N:24]=[C:25]4[CH:26]=[CH:27][CH:28]=3)[CH:21]=2)=[O:19])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993669HCID 21993669, compound

Product 1

HCID 21993603HCID 21993603, compoundYield 92.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 10.12 g (22.87 mM) of N-[3-(1-tert-butoxycarbonyl-4-piperidyl)propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in 100 ml of ethanol was added 9.4 ml (114.33 mM) of 12N-hydrochloric acid and the mixture was stirred at room temperature for 1 hour. The resulting precipitate was recovered by filtration and rinsed with small amounts of ethanol and ether to provide 8.79 g (92.5%) of the title compound as orange-colored crystals.

Workup

  1. filtrationThe resulting precipitate was recovered by filtration
  2. washrinsed with small amounts of ethanol and ether

Sources & evidence

ORD record
ord-9582fcba7f194fe0b0ffbe30400d34de
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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