Hydrochloric Acid → HCID 21993876, compound

HRID 1978447Notes

Reaction equation

HRID 1978447 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][NH:16][C:17]([C:19]2[S:29][C:28]3[N:30]4[C:21](=[CH:22][N:23]=[C:24]4[CH:25]=[CH:26][CH:27]=3)[CH:20]=2)=[O:18])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:31]>C(O)C>[ClH:31].[ClH:31].[ClH:31].[N:11]1([CH2:14][CH2:15][NH:16][C:17]([C:19]2[S:29][C:28]3[N:30]4[C:21](=[CH:22][N:23]=[C:24]4[CH:25]=[CH:26][CH:27]=3)[CH:20]=2)=[O:18])[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993802HCID 21993802, compound

Product 1

HCID 21993876HCID 21993876, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 3.60 g (8.38 mM) of N-[2-(4-tert-butoxycarbonyl-1-piperazinyl)ethan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in 100 ml of ethanol was added 3.4 ml (41.90 mM) of 12N-hydrochloric acid and the mixture was stirred at room temperature for one hour. The resulting crystals were collected by filtration and rinsed with small amounts of ethanol and ether to provide the title compound. Yield 3.36 g (91.4%, orange-colored crystals).

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washrinsed with small amounts of ethanol and ether

Sources & evidence

ORD record
ord-b1d8b10296ae493992ac1d07a140cca6
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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