Hydrochloric Acid → HCID 21993684, compound

HRID 1978452Notes

Reaction equation

HRID 1978452 reaction equation
C(OC([N:8]1[CH2:14][CH2:13][CH2:12][N:11]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[S:31][C:30]3[N:32]4[C:23](=[CH:24][N:25]=[C:26]4[CH:27]=[CH:28][CH:29]=3)[CH:22]=2)=[O:20])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:33]>C(O)C>[ClH:33].[ClH:33].[ClH:33].[N:11]1([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[S:31][C:30]3[N:32]4[C:23](=[CH:24][N:25]=[C:26]4[CH:27]=[CH:28][CH:29]=3)[CH:22]=2)=[O:20])[CH2:12][CH2:13][CH2:14][NH:8][CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993729HCID 21993729, compound

Product 1

HCID 21993684HCID 21993684, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 4250 mg (9.29 mM) of N-[3-(4-tert-butoxycarbonyl-2,3,5,6-tetrahydro-7H-1,4-diazepin-1-yl)propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in 100 ml of ethanol was added 3.8 ml (46.44 mM) of 12N-hydrochloric acid, and the mixture was stirred at room temperature for 1 hour. The resulting precipitate was recovered by filtration and rinsed with small amounts of ethanol and ether to provide the title compound. Yield 4020 mg (92.8%).

Workup

  1. filtrationThe resulting precipitate was recovered by filtration
  2. washrinsed with small amounts of ethanol and ether

Sources & evidence

ORD record
ord-7ee7c0207b1d4959940f30ee4cc2374a
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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