Hydrochloric Acid → N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide Dihydrochloride

HRID 1978461Notes

Reaction equation

HRID 1978461 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:30]>C(O)C>[ClH:30].[ClH:30].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21994006N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Product 1

HCID 21994005N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide Dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In a solution of 479 mg (1.18 mmol) of N-(1-benzylpiperidin-4-ylmethyl)-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 1.0 ml (4 mM) of 4N-HCl/methnol and the mixture was stirred at room temperature for several minutes. The solvent was then distilled off under reduced pressure and the residue was diluted with ethanol and diethyl ether. The resulting crystals were collected by filtration and rinsed with ethanol and diethyl ether to provide the title compound.

Workup

  1. distillationThe solvent was then distilled off under reduced pressure
  2. additionthe residue was diluted with ethanol and diethyl ether
  3. filtrationThe resulting crystals were collected by filtration
  4. washrinsed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-b19b43e1783142e29dc42b5848319df9
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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