Hydrochloride methanol → n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978468Notes

Reaction equation

HRID 1978468 reaction equation
[F:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1.[ClH:34].CO>C(O)C>[ClH:34].[ClH:34].[F:1][C:2]1[CH:33]=[CH:32][CH:31]=[CH:30][C:3]=1[O:4][CH2:5][CH2:6][CH2:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([C:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH:19]=2)=[O:17])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 21994003N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Product 1

HCID 21994085n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 244 mg (0.52 mM) of N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 1.0 ml (4.0 mM) of 4N-HCl/methanol. The solvent was distilled off under reduced pressure and the residue was purified by recrystallization to provide the title compound.

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. customthe residue was purified by recrystallization

Sources & evidence

ORD record
ord-e19fa9d90bc04d3aac069dfd736a4bc1
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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