HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide | HCID 21994003 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | n-[1-(3-(2-Fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride | HCID 21994085 | — |
Reaction Steps
To a solution of 244 mg (0.52 mM) of N-[1-(3-(2-fluorophenoxy)propan-1-yl)piperidin-4-ylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (4 ml) was added 1.0 ml (4.0 mM) of 4N-HCl/methanol. The solvent was distilled off under reduced pressure and the residue was purified by recrystallization to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235731B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-e19fa9d90bc04d3aac069dfd736a4bc1 |
| Source note | uspto-grants-2001_05 |