Hydrochloric Acid → HCID 178478892, compound

HRID 1978481Notes

Reaction equation

HRID 1978481 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][C@H:14]3[CH2:19][CH2:18][C@H:17]([CH2:20][NH:21][C:22]([C:24]4[S:34][C:33]5[N:35]6[C:26](=[CH:27][N:28]=[C:29]6[CH:30]=[CH:31][CH:32]=5)[CH:25]=4)=[O:23])[CH2:16][CH2:15]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:36]>C(O)C>[ClH:36].[ClH:36].[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][C@H:14]3[CH2:19][CH2:18][C@H:17]([CH2:20][NH:21][C:22]([C:24]4[S:34][C:33]5[N:35]6[C:26](=[CH:27][N:28]=[C:29]6[CH:30]=[CH:31][CH:32]=5)[CH:25]=4)=[O:23])[CH2:16][CH2:15]3)[CH2:9][CH2:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 178523381HCID 178523381, compound

Product 1

HCID 178478892HCID 178478892, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 549.7 mg (1.13 mM) of N-[trans-4-(4-phenylpiperidin-1-ylmethyl)-1-cyclohexylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (5 ml) was added 1.0 ml (12.0 mM) of 12N-hydrochloric acid and the mixture was stirred at room temperature for several minutes. After the reaction mixture was concentrated under reduced pressure, diethyl ether was added to the residue and the resulting crystals were collected by filtration and rinsed with ethanol and diethyl ether to provide the title compound as orange-colored crystals.

Workup

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure, diethyl ether
  2. additionwas added to the residue
  3. filtrationthe resulting crystals were collected by filtration
  4. washrinsed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-aee19d7efe1b4d61873895f1d501c7f3
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

Loading…