反应详情

To a solution of 549.7 mg (1.13 mM) of N-[trans-4-(4-phenylpiperidin-1-ylmethyl)-1-cyclohexylmethyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (5 ml) was added 1.0 ml (12.0 mM) of 12N-hydrochloric acid and the mixture was stirred at room temperature for several minutes. After the reaction mixture was concentrated under reduced pressure, diethyl ether was added to the residue and the resulting crystals were collected by filtration and rinsed with ethanol and diethyl ether to provide the title compound as orange-colored crystals.

1. concentrationAfter the reaction mixture was concentrated under reduced pressure, diethyl ether
2. additionwas added to the residue
3. filtrationthe resulting crystals were collected by filtration
4. washrinsed with ethanol and diethyl ether