Hydrochloric Acid → HCID 21994007, compound

HRID 1978496Notes

Reaction equation

HRID 1978496 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16](=[O:31])/[CH:17]=[CH:18]/[C:19]2[S:29][C:28]3[N:30]4[C:21](=[CH:22][N:23]=[C:24]4[CH:25]=[CH:26][CH:27]=3)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:32]>C(O)C>[ClH:32].[ClH:32].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][C:16](=[O:31])/[CH:17]=[CH:18]/[C:19]2[S:29][C:28]3[N:30]4[C:21](=[CH:22][N:23]=[C:24]4[CH:25]=[CH:26][CH:27]=3)[CH:20]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993956HCID 21993956, compound

Product 1

HCID 21994007HCID 21994007, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To the above crude (E)-5-[1-(tert-butoxycarbonyl)-piperidin-4-yl]-1-(5-thia-1,8b-diazaacenaphthylen-4-yl)-1-penten-3-one was added 5 ml of concentrated hydrochloric acid and the mixture was stirred at room temperature for 15 minutes. To this reaction mixture was added ethanol, followed by stirring, and the resulting precipitate was recovered by filtration and rinsed serially with ethanol and diethyl ether to provide the title compound.

Workup

  1. stirringby stirring
  2. filtrationthe resulting precipitate was recovered by filtration
  3. washrinsed serially with ethanol and diethyl ether

Sources & evidence

ORD record
ord-b8d82418373b46a2af9812f860e7a1a3
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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