Hydrochloric Acid → HCID 21994150, compound

HRID 1978498Notes

Reaction equation

HRID 1978498 reaction equation
[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][CH:13]([CH2:16][CH2:17][C:18](=[O:33])/[CH:19]=[CH:20]/[C:21]3[S:31][C:30]4[N:32]5[C:23](=[CH:24][N:25]=[C:26]5[CH:27]=[CH:28][CH:29]=4)[CH:22]=3)[CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:34]>CO>[ClH:34].[ClH:34].[C:1]1([CH2:7][CH2:8][CH2:9][N:10]2[CH2:11][CH2:12][CH:13]([CH2:16][CH2:17][C:18](=[O:33])/[CH:19]=[CH:20]/[C:21]3[S:31][C:30]4[N:32]5[C:23](=[CH:24][N:25]=[C:26]5[CH:27]=[CH:28][CH:29]=4)[CH:22]=3)[CH2:14][CH2:15]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993866HCID 21993866, compound

Product 1

HCID 21994150HCID 21994150, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 2 ml of methanol was dissolved 0.281 g (E)-5-[1-(3-phenylpropan-1-yl)piperidin-4-yl]-1-(5-thia-1,8b-diazaacenaphthylen-4-yl)-1-penten-3-one, followed by addition of a stoichiometric excess of methanolic hydrochloric acid, and the mixture was stirred for 10 minutes. This reaction mixture was concentrated and crystallized from ethanol-diethyl ether to provide the title compound.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. customcrystallized from ethanol-diethyl ether

Sources & evidence

ORD record
ord-689bffd7d4a9465684ba19e98cb11c87
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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