Hydrochloric Acid → HCID 10943925, compound

HRID 1978509Notes

Reaction equation

HRID 1978509 reaction equation
[N:1]1[CH:2]=[C:3]2[N:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]=13)[S:6][C:5]([C:13]([O:15]CC)=[O:14])=[CH:4]2.[OH-].[Na+].Cl>CO>[N:1]1[CH:2]=[C:3]2[N:12]3[C:7](=[CH:8][CH:9]=[CH:10][C:11]=13)[S:6][C:5]([C:13]([OH:15])=[O:14])=[CH:4]2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 12038723HCID 12038723, compound

Product 1

HCID 10943925HCID 10943925, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 2.2 g of ethyl 5-thia-1,8b-diazaacenaphthylene-4-carboxylate in methanol (6.6 ml) was added 1N-aqueous solution of sodium hydroxide (13 ml), and the mixture was stirred at room temperature for 2 hours. This reaction mixture was adjusted to pH 5 with 1N-hydrochloric acid under ice-cooling. Then, the mixture was stirred at room temperature for 1 hour. The resulting crystal cropwas harvested by filtration and dried to provide 5-thia-1,8b-diazaacenaphthylene-4-carboxylic acid (1.8 g, 94%).

Workup

  1. temperaturecooling
  2. stirringThen, the mixture was stirred at room temperature for 1 hour
  3. filtrationThe resulting crystal cropwas harvested by filtration
  4. customdried

Sources & evidence

ORD record
ord-6b2fd28440e644bca07ea0259235a9ae
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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