Hydrochloric Acid → HCID 21993979, compound

HRID 1978520Notes

Reaction equation

HRID 1978520 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[S:31][C:30]3[N:32]4[C:23](=[CH:24][N:25]=[C:26]4[CH:27]=[CH:28][CH:29]=3)[CH:22]=2)=[O:20])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:33]>C(O)C>[ClH:33].[ClH:33].[C:1]([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[S:31][C:30]3[N:32]4[C:23](=[CH:24][N:25]=[C:26]4[CH:27]=[CH:28][CH:29]=3)[CH:22]=2)=[O:20])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993898HCID 21993898, compound

Product 1

HCID 21993979HCID 21993979, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 0.715 g (1.60 mmol.) of N-[3-(4-benzoylpiperazin-1-yl)propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (10 ml) was added, at room temperature, 10 ml (120 mmol.) of 12N hydrochloric acid. The mixture was stirred for 16 hours, which was concentrated under reduced pressure. To the concentrate were added ethanol and diethyl ether. The resulting crystals were collected by filtration and washed with ethanol and diethyl ether to give the object compound as orange crystals. The yield was 0.715 g (86%).

Workup

  1. concentrationwhich was concentrated under reduced pressure
  2. additionTo the concentrate were added ethanol and diethyl ether
  3. filtrationThe resulting crystals were collected by filtration
  4. washwashed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-dceed731fa09410580e930d5883988b6
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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