Hydrochloric Acid → n-[1-[3-(2-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978528Notes

Reaction equation

HRID 1978528 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:15][CH2:14]1)#[N:2].[ClH:34]>C(O)C>[ClH:34].[ClH:34].[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:10][CH2:11][CH2:12][N:13]1[CH2:14][CH2:15][CH:16]([NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:17][CH2:18]1)#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993749N-[1-[3-(2-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Product 1

HCID 21993748n-[1-[3-(2-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochlorideYield 70%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an ethanol solution (8.0 ml) of N-[1-[3-(2-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (565 mg) was added conc. hydrochloric acid (3.0 ml). The mixture was stirred for 15 minutes at room temperature. The resulting crystals were collected by filtration and washed with ethanol to give the object compound (462 mg, 70%), m.p.234-240° C.

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol

Sources & evidence

ORD record
ord-7418d139f4d54df091a3197e88cd0233
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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