HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide | HCID 21994000 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride | HCID 21993999 | — |
Reaction Steps
To an ethanol solution (8.0 ml) of N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (565 mg) was added conc. hydrochloric acid. The mixture was stirred for 15 minutes at room temperature. The resulting crystals were collected by filtration and washed with ethanol (4622 mg, 70%), m.p.169-172° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235731B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-b7c75ca6a961497d8efd75e88ec569c2 |
| Source note | uspto-grants-2001_05 |