Hydrochloric Acid → N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978530Notes

Reaction equation

HRID 1978530 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:15][CH2:14]2)[CH:6]=[CH:7][CH:8]=1)#[N:2].[ClH:34]>C(O)C>[ClH:34].[ClH:34].[C:1]([C:3]1[CH:4]=[C:5]([O:9][CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:15][CH2:14]2)[CH:6]=[CH:7][CH:8]=1)#[N:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21994000N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Product 1

HCID 21993999N-[1-[3-(3-Cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To an ethanol solution (8.0 ml) of N-[1-[3-(3-cyanophenyloxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (565 mg) was added conc. hydrochloric acid. The mixture was stirred for 15 minutes at room temperature. The resulting crystals were collected by filtration and washed with ethanol (4622 mg, 70%), m.p.169-172° C.

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol (4622 mg, 70%), m.p.169-172° C.

Sources & evidence

ORD record
ord-b7c75ca6a961497d8efd75e88ec569c2
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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