Hydrochloric Acid → HCID 21993635, compound

HRID 1978534Notes

Reaction equation

[ClH:1].C(OC([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]2[S:31][C:30]3[N:32]4[C:23](=[CH:24][N:25]=[C:26]4[CH:27]=[CH:28][CH:29]=3)[CH:22]=2)=[O:20])[C:11](=[O:33])[CH2:10]1)=O)(C)(C)C>>[ClH:1].[ClH:1].[O:33]=[C:11]1[CH2:10][NH:9][CH2:14][CH2:13][N:12]1[CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]1[S:31][C:30]2[N:32]3[C:23](=[CH:24][N:25]=[C:26]3[CH:27]=[CH:28][CH:29]=2)[CH:22]=1)=[O:20]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 21993682HCID 21993682, compound

Product 1

HCID 21993635HCID 21993635, compound

Procedure

Concentrated hydrochloric acid (4.0 ml) was added to N-[3-(4-tert-butoxycarbonyl-2-oxopiperazin-1-yl)propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (1.53 g, 3.34 mmol) and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated in vacuo to give N-[3-(2-oxopiperazin-1-yl)propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride as an orange amorphous powder(1.53 g, quant.).

Workup

concentrationThe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record: ord-abd3f92296f244d6aee80451a7a966fa
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235731B1

Reaction notes

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