Hydrochloric Acid → N-[1-[3-(4-cyanophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

HRID 1978546Notes

Reaction equation

HRID 1978546 reaction equation
[ClH:1].[C:2]([C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:15][CH2:14]2)=[CH:6][CH:5]=1)#[N:3]>C(O)C>[ClH:1].[ClH:1].[C:2]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][CH:16]([NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[CH2:17][CH2:18]2)=[CH:8][CH:9]=1)#[N:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993829N-[1-[3-(4-cyanophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide

Product 1

HCID 21993831N-[1-[3-(4-cyanophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (1.5 ml) was added to a stirred solution of N-[1-[3-(4-cyanophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (298 mg, 0.672 mmol) in ethanol (4.0 ml) at room temperature. After stirring at room temperature for 1 hour, the reaction mixture was concentrated in vacuo to give N-[1-[3-(4-cyanophenyl)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride as an orange amorphous powdeer (324 mg, 93%).

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-67cb4e6575e0469db77dd249424737ec
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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