Hydrochloric Acid → 7-(4-Morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid hydrochloride

Participants

Reaction Conditions

Reaction Steps

A mixture of methyl 7-(4-morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (100 mg) and 6N hydrochloric acid (10 ml) was stirred at 70° C. for 4 hours and concentrated under reduced pressure. To the residue was added 2-propanol, and the resulting solid was collected by filtration and washed with 2-propanol and diethylether to give yellow powder of 7-(4-morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid hydrochloride (89.3 mg).

Provenance & Evidence