Hydrochloric Acid → 7-(4-Morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid hydrochloride

HRID 1978565Notes

Reaction equation

HRID 1978565 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:14]=[CH:15][C:16]4[S:22](=[O:24])(=[O:23])[CH2:21][CH2:20][C:19]([C:25]([O:27]C)=[O:26])=[CH:18][C:17]=4[CH:29]=3)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.[ClH:30]>>[ClH:30].[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:14]=[CH:15][C:16]4[S:22](=[O:24])(=[O:23])[CH2:21][CH2:20][C:19]([C:25]([OH:27])=[O:26])=[CH:18][C:17]=4[CH:29]=3)=[CH:9][CH:8]=2)[CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 21995678Methyl 7-(4-morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate

Product 1

HCID 702434687-(4-Morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid hydrochloride

Conditions

Temperature
70 °C

Procedure

A mixture of methyl 7-(4-morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (100 mg) and 6N hydrochloric acid (10 ml) was stirred at 70° C. for 4 hours and concentrated under reduced pressure. To the residue was added 2-propanol, and the resulting solid was collected by filtration and washed with 2-propanol and diethylether to give yellow powder of 7-(4-morpholinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid hydrochloride (89.3 mg).

Workup

  1. concentrationconcentrated under reduced pressure
  2. additionTo the residue was added 2-propanol
  3. filtrationthe resulting solid was collected by filtration
  4. washwashed with 2-propanol and diethylether

Sources & evidence

ORD record
ord-d337f4fd21744c87bb92424307ed5410
Source dataset
uspto-grants-2001_05
Patent number
US06235771B1

Reaction notes

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