反应详情

To a solution of methyl 7-(3,4-methylenedioxyphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (500 mg) in 1,2-dimethoxyethane (50 ml) was added 6N hydrochloric acid (30 ml), and the mixture was refluxed for 5 hours and concentrated under reduced pressure. Precipitates were collected by filtration and washed with 2-propanol and diethylether to give pale yellow crystals of 7-(3,4-methylenedioxyphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (415.7 mg).

1. temperaturethe mixture was refluxed for 5 hours
2. concentrationconcentrated under reduced pressure
3. customPrecipitates
4. filtrationwere collected by filtration
5. washwashed with 2-propanol and diethylether