Hydrochloric Acid → HCID 21995961, compound

HRID 1978571Notes

Reaction equation

HRID 1978571 reaction equation
[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([C:10]3[CH:11]=[CH:12][C:13]4[S:19](=[O:21])(=[O:20])[CH2:18][CH2:17][C:16]([C:22]([O:24]C)=[O:23])=[CH:15][C:14]=4[CH:26]=3)=[CH:4][C:3]=2[O:2]1.Cl>COCCOC>[CH2:1]1[O:9][C:8]2[CH:7]=[CH:6][C:5]([C:10]3[CH:11]=[CH:12][C:13]4[S:19](=[O:21])(=[O:20])[CH2:18][CH2:17][C:16]([C:22]([OH:24])=[O:23])=[CH:15][C:14]=4[CH:26]=3)=[CH:4][C:3]=2[O:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21995775HCID 21995775, compound

Product 1

HCID 21995961HCID 21995961, compoundYield 86.4%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

To a solution of methyl 7-(3,4-methylenedioxyphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (500 mg) in 1,2-dimethoxyethane (50 ml) was added 6N hydrochloric acid (30 ml), and the mixture was refluxed for 5 hours and concentrated under reduced pressure. Precipitates were collected by filtration and washed with 2-propanol and diethylether to give pale yellow crystals of 7-(3,4-methylenedioxyphenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (415.7 mg).

Workup

  1. temperaturethe mixture was refluxed for 5 hours
  2. concentrationconcentrated under reduced pressure
  3. customPrecipitates
  4. filtrationwere collected by filtration
  5. washwashed with 2-propanol and diethylether

Sources & evidence

ORD record
ord-b8a96c2598404308a933e15bc37b6974
Source dataset
uspto-grants-2001_05
Patent number
US06235771B1

Reaction notes

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