反应详情

温度

70 °C

To methyl 7-[4-(1-pyrrolidinyl)phenyl]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (270 mg) was added 6N hydrochloric acid (30 ml), and the mixture was stirred at 70° C. for 7 hours and concentrated under reduced pressure. To the residue was added 2-propanol to give crystals, which were collected by filtration. The crystals were washed with 2-propanol and hexane to give yellow crystals of 7-[4-(1-pyrrolidinyl)phenyl]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid hydrochloride (204 mg).

1. concentrationconcentrated under reduced pressure
2. additionTo the residue was added 2-propanol
3. customto give crystals, which
4. filtrationwere collected by filtration
5. washThe crystals were washed with 2-propanol and hexane