反应详情

温度

70 °C

To methyl 7-(4-piperidinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (600 mg) was added 6N hydrochloric acid (60 ml), and the mixture was stirred at 70° C. for 5 hours and concentrated under reduced pressure. To the residue was added ethanol, and to the mixture were added 8N sodium hydroxide solution and 1N sodium hydroxide solution to make the solution pH 6-7. The mixture was concentrated under reduced pressure to give solid, which was collected by filtration and washed with water, 2-propanol, acetone and diisopropylether to give yellow powder of 7-(4-piperidinophenyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (549.5 mg).

1. concentrationconcentrated under reduced pressure
2. additionTo the residue was added ethanol
3. additionto the mixture were added 8N sodium hydroxide solution and 1N sodium hydroxide solution
4. concentrationThe mixture was concentrated under reduced pressure
5. customto give solid, which
6. filtrationwas collected by filtration
7. washwashed with water, 2-propanol, acetone and diisopropylether