反应详情

温度

100 °C

In 1,2-dimethoxyethane (10.5 ml) was dissolved methyl 7-(5-methyl-2-thienyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (210 mg), and to the solution was added 6N hydrochloric acid (6.3 ml). The mixture was stirred at 100° C. for 14 hours, cooled to room temperature, extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give 7-(5-methyl-2-thienyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (180 mg).

1. temperaturecooled to room temperature
2. extractionextracted with ethyl acetate
3. washwashed with saturated brine
4. dry with materialdried with magnesium sulfate
5. customUnder reduced pressure, the solvent was evaporated