Hydrochloric Acid → HCID 21995735, compound

Participants

Reaction Conditions

Reaction Steps

In 1,2-dimethoxyethane (11.5 ml) was dissolved methyl 7-(5-chloro-2-thienyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (230 mg), and to the mixture was added 6N hydrochloric acid (9.2 ml). The mixture was stirred at 100° C. for 16 hours, cooled to room temperature, extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give 7-(5-chloro-2-thienyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (200 mg).

Provenance & Evidence