Hydrochloric Acid → HCID 21995735, compound

HRID 1978607Notes

Reaction equation

HRID 1978607 reaction equation
[Cl:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[CH:9][C:10]3[S:16](=[O:18])(=[O:17])[CH2:15][CH2:14][C:13]([C:19]([O:21]C)=[O:20])=[CH:12][C:11]=3[CH:23]=2)=[CH:4][CH:3]=1.Cl>COCCOC>[Cl:1][C:2]1[S:6][C:5]([C:7]2[CH:8]=[CH:9][C:10]3[S:16](=[O:17])(=[O:18])[CH2:15][CH2:14][C:13]([C:19]([OH:21])=[O:20])=[CH:12][C:11]=3[CH:23]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21995716HCID 21995716, compound

Product 1

HCID 21995735HCID 21995735, compoundYield 90.4%

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
100 °C

Procedure

In 1,2-dimethoxyethane (11.5 ml) was dissolved methyl 7-(5-chloro-2-thienyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylate (230 mg), and to the mixture was added 6N hydrochloric acid (9.2 ml). The mixture was stirred at 100° C. for 16 hours, cooled to room temperature, extracted with ethyl acetate, washed with saturated brine and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give 7-(5-chloro-2-thienyl)-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxylic acid (200 mg).

Workup

  1. temperaturecooled to room temperature
  2. extractionextracted with ethyl acetate
  3. washwashed with saturated brine
  4. dry with materialdried with magnesium sulfate
  5. customUnder reduced pressure, the solvent was evaporated

Sources & evidence

ORD record
ord-bdf0cfb8182d43698c9474cd3bfe72d7
Source dataset
uspto-grants-2001_05
Patent number
US06235771B1

Reaction notes

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