HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 21995935, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 1-Propanol, 3-chloro-2,2-dimethyl- | HCID 83407 | — |
| Catalyst | Bicyclo[2.2.1]heptane-1-methanesulfonic acid, 7,7-dimethyl-2-oxo-, (1S)- | HCID 18462 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 21995935 | HCID 21995935 | 72% |
Reaction Steps
To a solution of 3-chloro-2,2-dimethylpropanol (5.0 g) and 2,3-dihydropyran (4.12 g) in ethyl acetate (20 ml) was added camphor sulfonic acid (57 mg), and the mixture was stirred for 19 hours. To the mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with O.1N sodium hydroxide solution and saturated brine, and dried with magnesium sulfate. The solvent was evaporated under reduced pressure and distilled under reduced pressure (2 mmHg, 108° C.) to give colorless oil of 2-(3-chloro-2,2-dimethylpropoxy)tetrahydropyran (6.07 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06235771B1 |
| Source dataset | uspto-grants-2001_05 |
| ORD ID | ord-d7a5ef9066144f478b1604dba4cf9080 |
| Source note | uspto-grants-2001_05 |