反应详情

To a solution of 3-chloro-2,2-dimethylpropanol (5.0 g) and 2,3-dihydropyran (4.12 g) in ethyl acetate (20 ml) was added camphor sulfonic acid (57 mg), and the mixture was stirred for 19 hours. To the mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with O.1N sodium hydroxide solution and saturated brine, and dried with magnesium sulfate. The solvent was evaporated under reduced pressure and distilled under reduced pressure (2 mmHg, 108° C.) to give colorless oil of 2-(3-chloro-2,2-dimethylpropoxy)tetrahydropyran (6.07 g).

1. extractionthe mixture was extracted with ethyl acetate
2. washThe organic layer was washed with O
3. dry with material1N sodium hydroxide solution and saturated brine, and dried with magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. distillationdistilled under reduced pressure (2 mmHg, 108° C.)