L-Tartaric acid → HCID 86756842, compound

Participants

Reaction Steps

In THF (30 ml) was dissolved N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-7-[4-(2-propoxyethoxy)phenyl)]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide (1.0 g). To the solution was added L-tartaric acid (0.36 mg), and the mixture was stirred at room temperature for 12 hours. Under reduced pressure, the solvent was removed, and the residue was recrystallized from ethanol to give N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-7-[4-(2-propoxyethoxy)phenyl)]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide L-tartarate (Compound 134) (1.7 g).

Provenance & Evidence