L-Tartaric acid → HCID 86756842, compound

HRID 1978757Notes

Reaction equation

HRID 1978757 reaction equation
[O:1]=[S:2]1(=[O:16])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH:6]=[C:5]([C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1.[C:17]([OH:26])(=[O:25])[C@@H:18]([C@H:20]([C:22]([OH:24])=[O:23])[OH:21])[OH:19]>C1COCC1>[C:17]([OH:26])(=[O:25])[C@@H:18]([C@H:20]([C:22]([OH:24])=[O:23])[OH:21])[OH:19].[O:1]=[S:2]1(=[O:16])[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[CH:6]=[C:5]([C:13]([NH2:15])=[O:14])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 444305L-Tartaric acidHCID 53731419HCID 53731419, compound

Product 1

HCID 86756842HCID 86756842, compoundYield 182,966.797%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In THF (30 ml) was dissolved N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-7-[4-(2-propoxyethoxy)phenyl)]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide (1.0 g). To the solution was added L-tartaric acid (0.36 mg), and the mixture was stirred at room temperature for 12 hours. Under reduced pressure, the solvent was removed, and the residue was recrystallized from ethanol to give N-[4-[[N-methyl-N-(tetrahydropyran-4-yl)amino]methyl]phenyl]-7-[4-(2-propoxyethoxy)phenyl)]-1,1-dioxo-2,3-dihydro-1-benzothiepine-4-carboxamide L-tartarate (Compound 134) (1.7 g).

Workup

  1. customUnder reduced pressure, the solvent was removed
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-2252bb4e36994bc09e7a203a4e0267de
Source dataset
uspto-grants-2001_05
Patent number
US06235771B1

Reaction notes

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