反应详情

A suspension of 6-methoxybenzofuran-2-carboxylic acid (22.2 g) and copper powder (3.7 g) in quinoline (200 ml) was refluxed under nitrogen atmosphere for 2 hours and cooled, and to the suspension was added 2N hydrochloric acid. The mixture was extracted with ethyl acetate, and the organic layer was washed with 2N hydrochloric acid (6 times) and then washed with water and saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated to give dark brown oil of 6-methoxybenzofuran (17.1 g).

1. temperaturewas refluxed under nitrogen atmosphere for 2 hours
2. temperaturecooled
3. extractionThe mixture was extracted with ethyl acetate
4. washthe organic layer was washed with 2N hydrochloric acid (6 times)
5. washwashed with water and saturated brine
6. dry with materialdried with magnesium sulfate
7. customUnder reduced pressure, the solvent was evaporated