反应详情

2.6 g (0.015 mol) of 2-amino-4-chloro-6-isopropyl-1,3,5-triazine and 2.1 g (0.015 mol) of K2CO3 are initially introduced in 50 ml of acetonitrile. 2.5 g (0.015 mol) of 1-(4-fluorophenyl)-3-butylamine, dissolved in 20 ml of acetonitrile, are added dropwise to this solution. It is then heated to reflux for 3 hours. The solid constituents are then filtered off with suction and the filtrate is concentrated in a rotary evaporator. The residue is purified by means of column chromatography (eluent: ethyl acetate). Yield: 4.1 g (90% of theory).

1. additionare added dropwise to this solution
2. temperatureIt is then heated
3. temperatureto reflux for 3 hours
4. filtrationThe solid constituents are then filtered off with suction
5. concentrationthe filtrate is concentrated in a rotary evaporator
6. customThe residue is purified by means of column chromatography (eluent: ethyl acetate)