Water → 2-Chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]benzaldehyde

HRID 1978843Notes

Reaction equation

HRID 1978843 reaction equation
O.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:18])[F:17])[N:11]([CH3:20])[C:10]2=[O:21])=[CH:5][C:4]=1[CH:22]1OCC[O:23]1>C(O)(=O)C>[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[C:14](=[O:15])[CH:13]=[C:12]([C:16]([F:19])([F:17])[F:18])[N:11]([CH3:20])[C:10]2=[O:21])=[CH:5][C:4]=1[CH:22]=[O:23]

Participants

4

Reactant 2

HCID 962Water2×HCID 212012713-(4-Chloro-3-(1,3-dioxolan-2-yl)-phenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine

Product 1

HCID 212012252-Chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]benzaldehyde

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

5 ml of water were added to a solution of 1.9 g of 3-(4-chloro-3-(1,3-dioxolan-2-yl)-phenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 45 ml of glacial acetic acid. After stirring had been carried out for 12 hours at about 20-25° C. and for a further 5 hours at 40-50° C., 150 ml of water were stirred into the mixture. Thereafter, the precipitate formed was isolated, washed with water and petroleum ether and dried.

Workup

  1. customThereafter, the precipitate formed
  2. customwas isolated
  3. washwashed with water and petroleum ether
  4. customdried

Sources & evidence

ORD record
ord-2bdf1a84be6e4e0daef708fee7ac597b
Source dataset
uspto-grants-2001_05
Patent number
US06239074B1

Reaction notes

Loading…